DETAILS, FICTION AND LIGAZ SLOTS

DNA ligases seal 5′-PO4 and 3′-OH polynucleotide finishes by way of a few nucleotidyl transfer actions involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are vital guardians of genomic integrity, and ligase dysfunction underlies human genetic condition syndromes. Crystal buildings of DNA ligases bound to nucleotide and nucl